Case Study
Case Study
Case Study
Case Study
Case Study
20-Parallel Asymmetric Hydrogenation/Carbonylation Reactor for Syngenta
A cost-effective, reliable, flexible and easy to operate high throughput system
20-Parallel Asymmetric Hydrogenation/Carbonylation Reactor
The task
Acost-effective, reliable, flexible and easy to operate high throughput system
for screening of air- and moisture sensitive homogeneous and heterogeneous catalysts in a corrosive environment.
The ILS solution
To overcome this challenge we designed them a manually operated 20-parallel screening unit with two temperature blocks with 10 high-pressure reactors in each segment
Each temperature block of 10 reactors was split into 2-rows of 5 reactors operating at separate pressures, designed for 100barg and 200°C in this case.
The reaction media are contained completely within a HPLC-type, septum-sealed glass vials, which are magnetically stirred via a teflon-coated magnetic stirrer. The design used ensures there is no pressure gradient over the glass wall of this vessel meaning that reactions up to high pressure can be tested. There is zero cleaning required after reaction as the reagents are completely contained within the glass vial. The pressures vessels and needles have been manufactured in Hastelloy C for excellent corrosion protection.
The result
The tool was delivered in less than 5 months after the order
Because of the small footprint our unit required no additional infrastructure investment but could be installed in an existing fumehood. The handover & training was successfully finished in one week on-site at Syngenta. The ease of use combined with the fast delivery time quickly improved Syngenta’s screening capacity for very low amounts of moisture- and air-sensitive catalysts. Also the flexibility and extremely low (1-2 weeks) downtime per year make this system a very helpful R&D catalyst screening tool.
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